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| Clinical data | |
|---|---|
| Pronunciation | / s ɪ l ˈ d ɛ n ə f ɪ l / sil- DEN -ə-fil |
| Trade names | Viagra, Revatio, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a699015 |
| License data | EU EMA: by INN, US FDA: Sildenafil |
| Pregnancy category | AU: B1 US: B (No risk in non-human studies) |
| Routes of administration | By mouth (tablets), IV |
| ATC code | G04BE03 ( WHO ) |
| Legal status | |
| Legal status | AU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only In general: ℞ (Prescription only) |
| Pharmacokinetic data | |
| Bioavailability | 41% (mean) [1] |
| Protein binding | ~96% |
| Metabolism | Liver: CYP3A4 (major route), CYP2C9 (minor route) |
| Metabolites | N -desmethylsildenafil (~50% potency for PDE 5 ) |
| Elimination half-life | 3–4 hours |
| Excretion | Feces (~80%), urine (~13%) [2] |
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