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Promethazine

Clinical data
Trade names	Many [1]
AHFS/Drugs.com	Monograph
MedlinePlus	a682284
Pregnancy category	AU: C US: C (Risk not ruled out)
Routes of administration	Oral, rectal, IV, IM, topical
ATC code	D04AA10 ( WHO ) R06AD02 ( WHO )
Legal status
Legal status	AU: S3 (Pharmacist only) CA : OTC UK: P (Pharmacy medicines) (POM when injection), US: ℞-only South Africa: S5 IV S2 Oral
Pharmacokinetic data
Bioavailability	88% absorbed but after first-pass metabolism reduced to 25% absolute bioavailability [2]
Protein binding	93%
Metabolism	Hepatic glucuronidation and sulfoxidation
Elimination half-life	16–19 hours [2] [3]
Excretion	Renal and biliary

In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal or cardiac function, and of concomitant disease or other drug therapy. Hallucinations have also been reported.

Bone Marrow Depression Promethazine should be used with caution in patients with bone marrow depression. Labor And Delivery: It has a molecular weight of

Hematologic — Leukopenia, thrombocytopenia, thrombocytopenic purpura, agranulocytosis. Limited experience with dialysis indicates that it is not helpful.

Pharmacology

Only in cases of extreme overdosage or imitrex serotonin sensitivity do vital signs including respiration, pulse, blood pressure, temperature, and EKG need to be monitored. The antidotal efficacy of narcotic antagonists to dextromethorphan has not been established; note that any of the depressant effects of promethazine are not reversed by naloxone.

It should be used with caution in persons with seizure disorders or in persons who are using concomitant medications, such as narcotics or local anesthetics, which may also affect seizure threshold.

Carcinogenesis, Mutagenesis, Impairment Of Fertility: Dextromethorphan hydrobromide is a salt of the methyl ether of the dextrorotatory isomer of levorphanol, a narcotic analgesic.

Other Considerations overdosage Dextromethorphan: Pediatric Use: Neuroleptic malignant syndrome potentially fatal has also been reported. Excessive amounts of promethazine HCl relative to a narcotic may lead to restlessness and motor hyperactivity in the patient with pain; these symptoms usually disappear with adequate control of the pain.

promethazine synonym:

1. phenergan plain 25 mg
2. phenergan plain 25 mg
3. phenergan plain 25 mg
4. phenergan plain 25 mg

Acidosis and electrolyte losses should be corrected. A paradoxical reaction has been reported in children receiving single doses of 75 mg to mg orally, characterized by hyperexcitability and nightmares.

Anticholinergics — Concomitant use of other agents with anticholinergic properties should be undertaken with caution. Consideration should be given to the discontinuation of promethazine HCl and to the use of other drugs if these reactions occur. Limited data suggest that use of promethazine HCl during labor and delivery does not have an appreciable effect on the duration of labor or delivery and does not increase the risk of need for intervention in the newborn.

Promethazine info
Pill name	promethazine
Promethazine other name	phenergan plain, phenergan plain, phenergan plain, phenergan plain
Active substance	promethazine, promethazine
Best price	$43.20 for tablet
Besteller	60 tablets x 25 mg
Payment options	MasterCard, Visa, ACH, PayPal, American Express, eCheck
Round-the-clock Delivery options	EMS, AirMail, Trackable Courier Service
Guarantees	Guarantees of anonymity, quality assurance, return guarantees

Labor And Delivery: There are no adequate and well-controlled studies of promethazine in pregnant women. Long-term animal studies have not been performed to assess the carcinogenic potential of promethazine or of dextromethorphan.

Nursing Mothers:

There is no general agreement about specific pharmacological treatment regimens for uncomplicated NMS. Consideration should be given to the discontinuation of promethazine HCl and to the use of other drugs if these reactions occur.

Nonteratogenic Effects: Hallucinations have also been reported. Diagnostic pregnancy tests based on immunological reactions between HCG and anti-HCG may result in false-negative or false-positive interpretations. A paradoxical reaction has been reported in cipro fluoroquinolone receiving single doses of 75 mg to mg orally, characterized by hyperexcitability and nightmares.

Geriatric Use Clinical studies of promethazine hydrochloride and dextromethorphan hydrobromide syrup did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects – pharmacist's tip leads to prescription fraud arrests.

Labor And Delivery Limited data suggest that use of promethazine HCl during labor and delivery does not have an appreciable effect on the duration of labor or delivery and does not increase the risk of need for intervention in the newborn.

Nursing Mothers It is not known whether promethazine or dextromethorphan is excreted in human milk. Promethazine is a racemic compound.

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Promethazine hydrochloride and dextromethorphan hydrobromide oral solution

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Promethazine hydrochloride and dextromethorphan hydrobromide oral solution

Avoid prolonged exposure to the sun. Dextromethorphan should be used with caution in sedated patients, in the debilitated, and in patients confined to the supine position or viagra online australia customs fees. Antihistamines are contraindicated for use in the treatment of lower respiratory tract symptoms, including asthma. Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered mental status and evidence of autonomic instability irregular pulse or blood pressure, tachycardia, diaphoresis and cardiac dysrhythmias and buy himalaya liv 52 ds.

Long-term animal studies have not been performed to assess the carcinogenic potential of promethazine or of dextromethorphan. Promethazine hydrochloride occurs as a white to faint yellow, practically odorless, crystalline powder which slowly oxidizes and turns blue on prolonged exposure to air.

Children should be supervised to avoid potential harm in bike riding or in other hazardous activities. Caution should be exercised when promethazine and dextromethorphan is administered to a nursing woman.

Use of promethazine in patients with compromised respiratory function e. Teratogenic Effects — Pregnancy Category C: Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered mental status and evidence of autonomic instability irregular pulse or blood pressure, tachycardia, diaphoresis and cardiac dysrhythmias.

The treatment of overdosage with promethazine and dextromethorphan is essentially symptomatic and supportive. Use of promethazine in patients with compromised respiratory function e. Dosage must be individualized.

Promethazine hydrochloride and dextromethorphan hydrobromide oral solution

Dextromethorphan should be used with caution in sedated patients, in the debilitated, and in patients confined to the supine position. The following laboratory tests may be affected in patients who are receiving therapy with promethazine hydrochloride. An increase in blood glucose has been reported in patients receiving promethazine.

Activated charcoal orally or by lavage may be given, or sodium or magnesium sulfate orally as a cathartic. Dextromethorphan hydrobromide occurs as white crystals sparingly soluble in water and freely soluble in alcohol.

Consideration should be given to the discontinuation of promethazine HCl and to the use of other drugs if these reactions occur. An increase in blood glucose has been reported in patients receiving promethazine. Dextromethorphan hydrobromide occurs as white crystals sparingly soluble in water and freely soluble in alcohol. Convulsions may rarely occur.

Respiratory depression, nightmares, delirium, and agitated behavior have also been reported in some of these patients. Carcinogenesis, Mutagenesis, Impairment Of Fertility: It is not known whether promethazine or dextromethorphan is excreted in human milk.

Ambulatory patients should be told to avoid engaging in such activities until it is known that they do not become drowsy or dizzy from promethazine and dextromethorphan therapy	Hematologic — Leukopenia	In arriving at a diagnosis
Signs and symptoms of overdosage with promethazine HCl range from mild depression of the central nervous system and cardiovascular system to profound hypotension	Pregnancy Tests	Dosage must be individualized
Convulsions may rarely occur	Pregnancy Tests	See also " Nonteratogenic Effects "

Use of promethazine in patients with compromised respiratory function e. There are no animal or human data concerning the carcinogenicity, mutagenicity, or impairment of fertility with these drugs. The following laboratory tests may be affected in patients who are receiving therapy with promethazine hydrochloride.

The treatment of overdosage with promethazine and dextromethorphan is essentially symptomatic and supportive.

Promethazine should be used cautiously in persons with cardiovascular disease or with impairment of liver function. Drug Interactions:

In arriving at a diagnosis, it is important to identify cases where the clinical presentation includes both serious medical illness e. Other — Angioneurotic edema.

Nursing Mothers: Labor And Delivery: Administration of dextromethorphan may http://www.damove.com/hydroxyzine-2005173/voltarol-capsules accompanied by histamine release and should be used with caution in atopic children. Promethazine should be used cautiously in persons with cardiovascular disease or with impairment of liver function.

Phenergan syrup Promethazine 5mg use and side effect full hindi reviews Company Abott pharma

Use of promethazine in patients with compromised respiratory function e. The antidotal efficacy of narcotic antagonists to dextromethorphan has not been established; note that any of the depressant effects of promethazine are not reversed by naloxone. Other Considerations overdosage Dextromethorphan: It should be used with caution in persons with seizure disorders or in persons who are using concomitant medications, such as narcotics or local anesthetics, which may also affect seizure threshold.

Patients should be advised to report any involuntary muscle movements. Use of promethazine in patients with compromised respiratory function e. Acidosis and electrolyte losses should be corrected.

Lower Seizure Threshold Promethazine may lower seizure threshold.

Cardiovascular — Increased or decreased blood pressure, tachycardia, bradycardia, faintness. Dextromethorphan hydrobromide is a salt of the methyl ether of the dextrorotatory isomer of levorphanol, a narcotic analgesic.

Leukopenia and agranulocytosis have been reported, usually when promethazine HCl has aventis lasix used in association with other known marrow-toxic agents. Other Consideration overdosage Dextromethorphan Dextromethorphan may produce central excitement and mental confusion. Dextromethorphan hydrobromide 15 mg; promethazine hydrochloride 6.

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Analogous pharma:

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