Detrol la package insert, detrol la package insert
Detrol (tolterodine, tolterodine) 1 mg, tablets are debossed with pfizer on one side and vgr25.
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Clinical data | |
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Trade names | Detrol, Detrusitol |
AHFS/Drugs.com | Monograph |
MedlinePlus | a699026 |
Pregnancy category | AU: B3 US: C (Risk not ruled out) |
Routes of administration | By mouth |
ATC code | G04BD07 ( WHO ) |
Legal status | |
Legal status | AU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only |
Pharmacokinetic data | |
Bioavailability | 77% |
Protein binding | Approximately 96.3% |
Elimination half-life | 1.9–3.7 hours |
However, no overall differences were observed in safety between older and younger patients on tolterodine in the Phase 3, week, controlled clinical studies; therefore, no tolterodine dosage adjustment for elderly patients is recommended.
In another clinical study, elderly volunteers aged 71 through 81 years were given tolterodine immediate release 2 or 4 mg 1 or 2 mg bid. The chemical name of tolterodine tartrate is R -N,N-diisopropyl 2-hydroxymethylphenyl phenylpropanamine L-hydrogen tartrate.
Both urinary bladder contraction and salivation are mediated via cholinergic muscarinic receptors. Pregnant rabbits administered tolterodine subcutaneously at about 0. ECG monitoring is recommended in the event of overdosage.
Exposure levels of other metabolites of tolterodine e.
The main effects of tolterodine at 1 and 5 hours were an increase in residual urine, reflecting an incomplete emptying of the bladder, and a decrease in detrusor pressure. After oral cardizem 240, tolterodine is metabolized in the liver, resulting in the formation of 5-hydroxymethyl tolterodine 5-HMTthe major pharmacologically active metabolite.
Table 2 summarizes the mean change from baseline to steady state in corrected QT interval QTc relative to placebo at the time of detrol la package insert tolterodine 1 hour and moxifloxacin 2 hour concentrations.
Detrol la package insert
In multiple-dose studies in which tolterodine immediate release 4 mg 2 mg bid was administered, serum concentrations of tolterodine and of 5-HMT were similar in healthy elderly volunteers aged 64 through 80 years and healthy young volunteers aged less than 40 years.
In a study of tolterodine immediate release conducted in cirrhotic patients Child-Pugh Class A and Bthe elimination half-life of tolterodine immediate release was longer in cirrhotic patients mean, 7. The main effects of tolterodine at 1 and 5 hours were an increase http://www.damove.com/quibron-t-2005173/fluoxetine-10mg-tablets-price residual urine, reflecting an incomplete emptying of the bladder, and a decrease in detrusor pressure, .
In the U.
Effects on urodynamic parameters before and 1 and 5 hours after a single 6. The clearance of orally administered tolterodine immediate release was substantially lower in cirrhotic patients 1.
The clearance of orally administered tolterodine immediate release was substantially lower in cirrhotic patients 1. The recommended dose for patients with severe renal impairment CCr: Reports of aggravation of symptoms of dementia e.
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detrol other name:- tolterodina 1 mg
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The main effects of tolterodine at 1 and 5 hours were an increase in residual urine, reflecting an incomplete emptying of the bladder, and a decrease in detrusor pressure. Aggressive, abnormal, and hyperactive behavior and attention disorders occurred in 2.
Because these spontaneously reported events are from the worldwide post-marketing experience, the frequency of events and the role of tolterodine in their causation cannot be reliably determined. Table is propecia otc.
QT interval was measured over a hour period following dosing, including the time of peak plasma concentration Tmax of tolterodine and at steady state Day 4 of dosing.
The change in heart rate with moxifloxacin was 0.
Detrol info | |
---|---|
Drug name | detrol |
Detrol alternative name | tolterodinum, toltérodine, tolter, toltérodine |
Active substance | tolterodine, tolterodine |
Best price | $1.5 for tablet |
Besteller | 10 tablets x 1 mg |
Payment options | MasterCard, Visa, ACH, PayPal, American Express, eCheck |
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Its structure is: QT interval was measured manually and by machine, and data from both are presented.
The chemical name of tolterodine tartrate is R -N,N-diisopropyl 2-hydroxymethylphenyl phenylpropanamine L-hydrogen tartrate. The active moiety, tolterodine, is a muscarinic receptor antagonist. The main effects of tolterodine at 1 and 5 hours were an increase in residual urine, reflecting an incomplete emptying of the bladder, and a decrease in detrusor pressure.
The clearance of orally administered tolterodine immediate release was substantially lower in cirrhotic patients 1. In a study of tolterodine immediate release conducted in cirrhotic patients Child-Pugh Class A and Bthe elimination half-life of tolterodine immediate release was longer in cirrhotic patients mean, 7.
Both urinary bladder contraction and salivation are mediated via cholinergic muscarinic receptors. Effects on urodynamic parameters before and 1 and 5 hours after a single 6.
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The partition coefficient Log D between n-octanol and water is 1. In multiple-dose studies in which tolterodine immediate release 4 mg 2 mg bid was administered, serum concentrations of tolterodine and of 5-HMT were similar in healthy elderly volunteers aged 64 through 80 years and healthy young volunteers aged detrol la package insert than 40 years. Reports of aggravation of symptoms of dementia e. Pregnant rabbits administered tolterodine subcutaneously at about 0.
However, no overall differences were observed in safety between older and younger patients on tolterodine in the Click 3, week, controlled clinical studies; therefore, no tolterodine dosage adjustment for elderly patients is recommended. Its structure is:
The clearance of orally administered tolterodine immediate release was substantially lower in cirrhotic patients 1. Pregnant rabbits administered tolterodine subcutaneously at about 0. Based on limited data, tolterodine is cleocin ovuli into the milk in mice in low amounts see Data.
Effects on urodynamic parameters before and 1 and 5 hours after a single 6.
The child fully recovered. The recommended dose for patients with severe renal impairment CCr: Reports of aggravation of symptoms of dementia e.
Detrol la package insert | ||||||
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It is soluble in methanol | Table 2 | |||||
It is soluble in methanol | In another clinical study | |||||
After oral administration | Because these spontaneously reported events are from the worldwide post-marketing experience | |||||
The active moiety | Aggressive | |||||
The partition coefficient Log D between n-octanol and water is 1 | Its structure is | |||||
In another clinical study | Effects on urodynamic parameters before and 1 and 5 hours after a single 6 |
2.1 Dosing Information
Both tolterodine and 5-HMT exhibit a high specificity for muscarinic receptors, since both show negligible activity or affinity for other neurotransmitter receptors and other potential cellular targets, such as calcium channels. The pKa value is 9.
Reports of aggravation of symptoms of dementia e. The change in heart rate with moxifloxacin was 0. The partition coefficient Log D between n-octanol and water is 1.
Animal Data The use of radiolabeled tolterodine in pregnant mice produced milk:
QT interval was measured manually and by machine, and data from both are presented. A month-old child who ingested 5 to 7 tolterodine immediate release 2 mg tablets was treated with a suspension of activated charcoal and was hospitalized overnight with symptoms of dry mouth. The pKa value is 9. However, no overall differences were observed in safety between older detrol la package insert younger patients on tolterodine in the Phase 3, week, controlled clinical studies; therefore, no tolterodine dosage adjustment for elderly patients is recommended.
In another clinical study, elderly volunteers macrobid and macrodantin 71 through 81 years were given tolterodine immediate release 2 or 4 mg 1 or 2 mg bid. The active moiety, tolterodine, is a muscarinic receptor antagonist.
Effects on urodynamic parameters before and 1 and 5 hours after a single 6. The clearance of orally administered tolterodine immediate release was substantially lower in cirrhotic patients 1.
Its structure is: Reports of aggravation of symptoms of dementia e. ECG monitoring is recommended in the event of overdosage. The child fully recovered.
The partition coefficient Log D between n-octanol and water is 1. The recommended dose for patients with severe renal impairment CCr: Aggressive, abnormal, and hyperactive behavior and attention disorders occurred in 2 - detrol 1mg.
In the U. These findings are consistent with an antimuscarinic action on the lower urinary tract. Table 2 summarizes the mean change from baseline to steady state in corrected QT interval QTc relative to placebo at the time of peak tolterodine 1 hour and moxifloxacin 2 hour concentrations.
QT interval was measured over a hour period following dosing, including the time of detrol la package insert plasma concentration Tmax of tolterodine and at steady state Day 4 of dosing.
In a study of tolterodine immediate release conducted in cirrhotic patients Child-Pugh Class A and Bthe elimination half-life of tolterodine immediate release was longer in cirrhotic patients mean, 7. ECG monitoring is recommended in the event of overdosage.
Effects on urodynamic parameters before and 1 and 5 hours after a single 6.
The active moiety, tolterodine, is a muscarinic receptor antagonist. Both urinary bladder contraction and salivation are mediated via cholinergic muscarinic receptors.
These findings are consistent with an antimuscarinic action on the lower urinary tract. The pKa value is 9. However, no overall differences were observed in safety between older and younger patients on tolterodine in the Phase 3, week, controlled clinical studies; therefore, no tolterodine dosage adjustment for elderly patients is recommended.
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QT interval was measured manually and by machine, and data from both are presented. ECG monitoring is recommended in the event of overdosage and .
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The chemical name of tolterodine tartrate is R -N,N-diisopropyl 2-hydroxymethylphenyl phenylpropanamine L-hydrogen tartrate.
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QT interval was measured over a hour period following dosing, including the time of peak plasma concentration Tmax of tolterodine and at steady state Day 4 of dosing. However, no overall differences were observed in safety between older and younger patients on tolterodine in the Phase 3, week, controlled clinical studies; therefore, no tolterodine dosage adjustment for elderly patients is recommended.
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